GLP-1(S).
Semaglutide is a synthetic analog of human glucagon-like peptide-1 (GLP-1) with 94% homology to native GLP-1. With the molecular formula C₁₈₇H₂₉₁N₄₅O₅₉ and a molecular weight of 4113.6 g/mol (CAS: 910...
Lab Verified
Clinical Grade
PMID Cited
Mechanism of Action.
Published preclinical research has characterized the following molecular pathways and receptor interactions for GLP-1(S).
GLP-1 Receptor
Semaglutide binds to GLP-1 receptors with high affinity, activating Gs-proteins and increasing intracellular cAMP levels in beta-cell models.
Albumin Binding
The C18 fatty di-acid side chain enables reversible albumin binding, extending circulation half-life in biochemical studies.
Receptor Internalization
Published studies indicate Semaglutide promotes receptor internalization with distinct kinetics compared to native GLP-1.
Clinical Literature
Research review on GLP-1(S) molecular characterization.
Preclinical studies have characterized the molecular properties and receptor binding profiles of GLP-1(S) in standardized assay systems.
GLP-1(S) structure-activity relationship analysis.
Structure-activity relationship studies have examined the functional domains and binding characteristics of GLP-1(S) in cell-free and cell-based systems.
RESEARCH USE ONLY: This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease. Not evaluated by the FDA. Must be 21+ to purchase.
Related Compounds.
Metabolic5-Amino-1MQ
$36.00C10H11N2 (free base) · 159.21 g/mol (free base)
For in vitro research use only. Not for human consumption.
MetabolicAICAR
$57.00C9H14N4O5 · 258.23 g/mol
For in vitro research use only. Not for human consumption.
MetabolicAOD9604
$48.00C78H123N23O23S2 · 1815.12 g/mol
For in vitro research use only. Not for human consumption.
Related Research & Analysis
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GLP-1 Receptor Agonist Peptides: Research Use
Technical review of GLP-1 receptor agonist molecular mechanisms, structural modifications, and binding pharmacology. Analysis of receptor signaling pathways and published in vitro findings.